ST. PETERSBURG — The Tampa Bay Rays could clinch their first postseason berth since 2023 as early as Friday night when they open a weekend series against the Houston Astros at Tropicana Field, a matchup pitting the AL East and AL West leaders — and two MVP frontrunners — against each other with October implications for both clubs.

Tampa Bay holds a three-game lead over the Yankees in the AL East, identical to Houston’s three-game advantage over the Rangers in the AL West. The Rays have been dominant at Tropicana Field all season, and the club would like to lock up a playoff spot before heading to a four-game, three-day series at Yankee Stadium from Sept. 22-24 that could decide the division.

The series spotlight falls on the AL home run title race between Rays third baseman Junior Caminero, who leads with 39, and Astros slugger Yordan Alvarez at 38. Alvarez is chasing what would be the first AL Triple Crown since Miguel Cabrera in 2012, leading the league in all three slash-line categories at .310/.427/.590 while also topping the leaderboards in runs scored, walks, OPS+ and total bases. Caminero counters with an argument voters may find persuasive: he is the best player on the AL’s best team and has not missed a single start this season, while Alvarez has played only 23 of his 145 games in left field, serving primarily as designated hitter.

Tampa Bay’s lineup has surged behind Trade Deadline acquisition Liam Hicks and the red-hot Chandler Simpson, who is hitting .308, along with Yandy Díaz (.305) and Jonathan Aranda. The top of the rotation — Drew Rasmussen, Nick Martinez and Freddy Peralta — has been excellent, and closer Bryan Baker has converted 28 consecutive save opportunities. But injuries have thinned the roster: Shane McClanahan is out of the rotation, relievers Garrett Cleavinger and Manuel Rodríguez are sidelined, and defensive anchor Taylor Walls is unavailable at shortstop.

Houston arrives with concerns of its own. The Astros’ offense is slashing .233/.305/.391 since Aug. 1, a six-week skid driven by prolonged slumps from Jeremy Peña (.190/.240/.362 with five homers over 33 games) and Alvarez, who has hit just three homers since Aug. 1. The pitching staff has compensated: Astros starters posted a 3.06 ERA with six quality starts over 19 games since Aug. 21, led by Hunter Brown, who has thrown 92 innings this year after missing two and a half months with a shoulder strain, and Hayden Wesneski, who has logged 45 2/3 innings since returning from Tommy John surgery. Houston has 15 games remaining, nine of them against sub-.500 clubs in the Royals, Mariners and Athletics, but still faces six games against first-place teams in the Rays and Braves.

Alvarez’s batting title is far from secure, with Simpson and Díaz within striking distance, and Caminero and Pete Alonso challenging him for the AL RBI lead. If Alvarez fails to lock up all three Triple Crown categories, MVP voters could tilt toward Caminero — especially if the Rays secure the AL’s top seed. The three-game series at Tropicana Field opens Friday night.